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COMPACTIN (Mevastatin) is not used in treatment of hyperlipidemias because of multiple side effects but it is the only source for Pravastatin production at present.At first stage strain of Penicillium citrinum produces Compactin and then the strain of Streptomyces carbophilus by microbial transformation reverts it into Pravastatin.
Compactin Technology (production and recovery)
Initial productivity of the strain of Penicillium citrinum was 40 mg/L.
Production technology
Strain-producer:
Penicillium citrinum (mutants obtained in our R&D Department from wild strain)
Product:
Compactin (Mevastatin)
Potency:
>15 G/L
Scale:
Shake flasks, 3L fermentor, 30L fermentor
Fermentation time:
216-264 hours
Main raw material list:
Soybean powder, ,Soybean peptone or Casein hydrolizate, sucrose/glycerol, mineral salts (NaNO3, MgSO4)
Analysis method:
HPLC
Compactin Recovery Technology
Though Compactin is used only as intermediate for Pravastatin production and does not require high purity we aimed to obtain as high as possible purity. This will result in economic effect in the process of Pravastatin production.
Parameters for Recovery technology are as follows:
Yield: not less than 60% (up to 80%)
Purity: not less then 90% (up to 95%)
TECHNOLOGY TRANSFER PROCEDURE AND APPROXIMATE TERMS FOR EACH STEP
PROCEDURE >> TERMS
1. Contract signing
>> As soon as all the details agreed by both parties
2. Down-payment confirmation >> Two weeks after Contract come into force
3. Technology description Transfer >> One week after down-payment confirmed
4. Technology Verification >> Not later than two months after Technology description Transfer; Compactin verification procedure: 2 weeks
5. Final payment confirmation in accordance to verified results as per Contract >> Not later than two weeks after Verification results are reported in Verification Certificates
6. Post-Technology transfer service (strain re-supplying, technical help, consultations) >> Two years after technology Transfer completed
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